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KMID : 0043320040270111161
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Archives of Pharmacal Research
2004 Volume.27 No. 11 p.1161 ~ p.1167
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Voltammetric Studies of Cu-Adriblastina Complex and its Effect on ssDNA-Adriblastina Interaction at In Situ Mercury Film Electrode
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D.Abd El Hady
M.Ibrahim Abdel Hamid
M.Mahmoud Sellem
N.Abo E Maali
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Abstract
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Adriblastina, a cancerostatic anthracycline antibiotic, causes considerable oxidative damage to DNA molecules. The interaction of this compound with DNA was investigated using Osteryoung square wave stripping voltammetry (OSWSV) and cyclic voltammetry (CV) at an in situ mercury film electrode. It was found that the equilibrium constant of the bonded oxidized form of the drug was 63 times bigger more important than that of the bonded reduced form. Copper forms 1 metal: 2 drug stoichiometry complex which is highly stable compared to ssDNA-drug interaction and consequently inhibited the drug biochemical damaging effects. Copper complex offered sub-nanogram determination of adriblastina in aqueous and urine media.
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KEYWORD
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Voltammetry, Copper complex, Adriblastina, ssDNA, Urine
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